BDBM220866 US11472769, Compound BI-1467335-(PXS-4728A)::US9302986, 23

SMILES CC(C)(C)NC(=O)c1ccc(OC\C(CN)=C\F)cc1

InChI Key InChIKey=OWNSXNXYELKDSO-DHZHZOJOSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 220866   

TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM220866(US11472769, Compound BI-1467335-(PXS-4728A) | US93...)
Affinity DataIC50: >1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human MAO-B (0.06 mg/mL; Sigma Aldrich) was used as source of MAO-B enzyme activities. The assay was performed in a similar way as for hu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM220866(US11472769, Compound BI-1467335-(PXS-4728A) | US93...)
Affinity DataIC50: <1.00E+5nMpH: 7.4Assay Description:Briefly, HMEC cell expressing human SSAO/VAP-1 were grown in several 10 cm petri dishes, once the cells reached 100% confluency, cells were harvested...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Rattus norvegicus (Rat))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM220866(US11472769, Compound BI-1467335-(PXS-4728A) | US93...)
Affinity DataIC50: <1.00E+5nMpH: 7.4Assay Description:Abdominal fat from BALB/c mice, Wistar or Sprague Dawley rats, which are tissues enriched with SSAO/VAP-1-were surgically removed. For every gram of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRetina-specific copper amine oxidase(Homo sapiens (Human))
Eccogene (Shanghai)

US Patent
LigandPNGBDBM220866(US11472769, Compound BI-1467335-(PXS-4728A) | US93...)
Affinity DataIC50: <20nMAssay Description:Amine oxidase activity of recombinant hSSAO, hMAO-A, and hMAO-B isoforms are measured using the MAO-Glo assay kit (Promega, V1402). Ten nL test compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM220866(US11472769, Compound BI-1467335-(PXS-4728A) | US93...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant VAP-1 using benzylamine as substrate incubated for 30 mins followed by substrate addition measured every 2.5 mins for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Eccogene (Shanghai)

US Patent
LigandPNGBDBM220866(US11472769, Compound BI-1467335-(PXS-4728A) | US93...)
Affinity DataIC50: >3.00E+4nMAssay Description:Amine oxidase activity of recombinant hSSAO, hMAO-A, and hMAO-B isoforms are measured using the MAO-Glo assay kit (Promega, V1402). Ten nL test compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM220866(US11472769, Compound BI-1467335-(PXS-4728A) | US93...)
Affinity DataIC50: <1.00E+4nMAssay Description:Amine oxidase activity of recombinant hSSAO, hMAO-A, and hMAO-B isoforms are measured using the MAO-Glo assay kit (Promega, V1402). Ten nL test compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM220866(US11472769, Compound BI-1467335-(PXS-4728A) | US93...)
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
In DepthDetails US Patent