BDBM227552 US9339486, CP55,940

SMILES CCCCCCC(C)(C)c1ccc(C2CC(O)CCC2CCCO)c(O)c1

InChI Key InChIKey=YNZFFALZMRAPHQ-UHFFFAOYSA-N

Data  2 KI  4 EC50

PDB links: 5 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 227552   

TargetCannabinoid receptor 2(Homo sapiens (Human))
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM227552(US9339486, CP55,940)
Affinity DataKi:  1.80nMpH: 7.4Assay Description:Cell membrane homogenates (15 μg protein) were incubated for 120 min at 37° C. with 0.8 nM [3H]WIN 55212-2 (the reference standard [Munro, 1993 ...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM227552(US9339486, CP55,940)
Affinity DataKi:  3.40nMpH: 7.4Assay Description:Cell membrane homogenates (25 μg protein) were incubated for 120 min at 37° C. with 0.5 nM [3H]CP 55940 (the reference standard [Rinaldi-Carmona...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM227552(US9339486, CP55,940)
Affinity DataEC50:  0.140nMAssay Description:The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ...More data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM227552(US9339486, CP55,940)
Affinity DataEC50:  6.5nMAssay Description:Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma...More data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Rattus norvegicus (Rat))
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM227552(US9339486, CP55,940)
Affinity DataEC50:  1.13nMAssay Description:The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCannabinoid receptor 1(Homo sapiens (Human))
The Cleveland Clinic Foundation

US Patent
LigandPNGBDBM227552(US9339486, CP55,940)
Affinity DataEC50:  9nMAssay Description:Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma...More data for this Ligand-Target Pair