BDBM239042 US10028934, Compound 42::US10478423, Cpd. 42::US9408850, 42::US9597317, 42

SMILES C[N+]1([O-])CCN(c2ccc(C(=O)Nc3n[nH]c4cc(OCCOCc5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1

InChI Key InChIKey=GTHMLHGDEWZDBE-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 239042   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 239042BDBM239042(US9408850, 42 | US10028934, Compound 42 | US959731...)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 239042BDBM239042(US9408850, 42 | US10028934, Compound 42 | US959731...)
Affinity DataIC50: 50nMpH: 7.9Assay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 239042BDBM239042(US9408850, 42 | US10028934, Compound 42 | US959731...)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [564-993](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 239042BDBM239042(US9408850, 42 | US10028934, Compound 42 | US959731...)
Affinity DataIC50: 50nMpH: 7.9 T: 2°CAssay Description:The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 239042BDBM239042(US9408850, 42 | US10028934, Compound 42 | US959731...)
Affinity DataIC50: 55nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 239042BDBM239042(US9408850, 42 | US10028934, Compound 42 | US959731...)
Affinity DataIC50: 55nMpH: 7.9Assay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [544-976](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 239042BDBM239042(US9408850, 42 | US10028934, Compound 42 | US959731...)
Affinity DataIC50: 55nMpH: 7.9Assay Description:The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 239042BDBM239042(US9408850, 42 | US10028934, Compound 42 | US959731...)
Affinity DataIC50: 55nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent