BDBM50305452 CHEMBL591578::methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-1-cyclohexyl-3-(methylamino)propan-2-ylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate
SMILES CNC[C@H](CC1CCCCC1)NC(=O)N1CCC[C@H](C1)[C@@H](OCCNC(=O)OC)c1cccc(Cl)c1
InChI Key InChIKey=JQRFWBUMHAMLAJ-VJTSUQJLSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50305452
Affinity DataIC50: 0.480nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
Affinity DataIC50: 0.820nMAssay Description:Inhibition of human recombinant renin assessed as decrease in plasma renin activity by competitive radioimmunoassay in presence of human plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.480nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of CYP3A4 using testosterone as substrate in human liver microsome for 20 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.820nMAssay Description:Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair