BDBM50307987 CHEMBL604712::N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-3,5-difluorobenzamide

SMILES CC(C)(C)C(=O)N1Cc2c(NC(=O)c3cc(F)cc(F)c3)[nH]nc2C1(C)C

InChI Key InChIKey=QXBKFUBBGBWPCJ-UHFFFAOYSA-N

Data  36 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50307987   

TargetAurora kinase B(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aurora B by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50:  450nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50:  140nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50:  90nMAssay Description:Inhibition of CDK2/cyclin E by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKCalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human CDK2/cyclin A expressed in Escherichia coli BL21 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50:  3.63E+3nMAssay Description:Inhibition of GSK3-beta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-ABL by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDC7 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aurora A by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALK by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR3 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RET by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKAalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PAK4 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek6(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of NEK6 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LCK by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of cKit by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGF1R by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FLT3 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(CHEMBL604712 | N-[5-(2,2-Dimethylpropanoyl)-6,6-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CHK1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed