BDBM50530254 CHEMBL4475043
SMILES C[C@@H]1OCC2(CCN(CC2)c2cnc3c(n[nH]c3n2)-c2cccc(Cl)c2Cl)[C@@H]1N
InChI Key InChIKey=HNONCNSCKGVMAR-BBATYDOGSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50530254
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Novartis Pharmaceuticals
Curated by ChEMBL
Novartis Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Pharmaceuticals
Curated by ChEMBL
Novartis Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Novartis Pharmaceuticals
Curated by ChEMBL
Novartis Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Pharmaceuticals
Curated by ChEMBL
Novartis Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Pharmaceuticals
Curated by ChEMBL
Novartis Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of hERG ion channel incubated for 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Novartis Pharmaceuticals
Curated by ChEMBL
Novartis Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Novartis Pharmaceuticals
Curated by ChEMBL
Novartis Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Novartis Pharmaceuticals
Curated by ChEMBL
Novartis Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Novartis Pharmaceuticals
Curated by ChEMBL
Novartis Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair