TargetDihydrofolate reductase(Homo sapiens (Human))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataKi: 0nMAssay Description:Competitive inhibition of human recombinant DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolateMore data for this Ligand-Target Pair
Affinity DataKi: 0.00140nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.00140nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.00140nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.00150nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.00230nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.0130nMAssay Description:Inhibition of human factor 10a using S-2765 as substrate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.0190nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.0300nMAssay Description:Competitive inhibition of Candida albicans DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolateMore data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.0460nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.0690nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.0920nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.146nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Binding affinity to CB2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.336nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Binding affinity to CB2 receptorMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Competitive inhibition of human recombinant DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolateMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Binding affinity to CB1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 3.70nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 4.20nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >5nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: >5nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 5.5nMAssay Description:Binding affinity to CB2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Binding affinity to CB1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of human trypsin using S-2222 as substrate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 16.4nMAssay Description:Binding affinity to CB1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of human thrombin using S-2366 as substrate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 480nMAssay Description:Competitive inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair