Found 43 of ic50 for monomerid = 50017712 TargetSynaptic vesicular amine transporter [V41A](Rattus norvegicus (Rat))
Hebrew University Of Jerusalem
Hebrew University Of Jerusalem
Affinity DataIC50: 1.30nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.80nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter [G308P](Rattus norvegicus (Rat))
Hebrew University Of Jerusalem
Hebrew University Of Jerusalem
Affinity DataIC50: 2nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter [V41I](Rattus norvegicus (Rat))
Hebrew University Of Jerusalem
Hebrew University Of Jerusalem
Affinity DataIC50: 3.70nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter [P314G](Rattus norvegicus (Rat))
Hebrew University Of Jerusalem
Hebrew University Of Jerusalem
Affinity DataIC50: 3.80nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter [P314T](Rattus norvegicus (Rat))
Hebrew University Of Jerusalem
Hebrew University Of Jerusalem
Affinity DataIC50: 4.30nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter [G308A](Rattus norvegicus (Rat))
Hebrew University Of Jerusalem
Hebrew University Of Jerusalem
Affinity DataIC50: 4.5nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter [P314L](Rattus norvegicus (Rat))
Hebrew University Of Jerusalem
Hebrew University Of Jerusalem
Affinity DataIC50: 4.90nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter [V132A](Rattus norvegicus (Rat))
Hebrew University Of Jerusalem
Hebrew University Of Jerusalem
Affinity DataIC50: >50nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter [V132G](Rattus norvegicus (Rat))
Hebrew University Of Jerusalem
Hebrew University Of Jerusalem
Affinity DataIC50: >100nMpH: 8.5Assay Description:The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of Fluo-3-AM efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of P-glycoprotein by Hoechst assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.24E+3nMAssay Description:Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 5.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of Tetramethylrosamine efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 6.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of JC-1 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetQuinolone resistance protein NorA(Staphylococcus aureus)
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux dose response curve based fluorometric assayMore data for this Ligand-Target Pair
TargetQuinolone resistance protein NorA(Staphylococcus aureus)
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of NorA efflux pump in Staphylococcus aureus K3092 assessed as inhibition of EtBr effluxMore data for this Ligand-Target Pair
TargetQuinolone resistance protein NorA(Staphylococcus aureus)
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B by spectrofluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.35E+3nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human BSEP expressed in HEK293 cell membrane vesicles assessed as reduction in 3H-TCA uptake incubated for 5 mins by radiodetection met...More data for this Ligand-Target Pair
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
TargetQuinolone resistance protein NorA(Staphylococcus aureus)
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Universita` Degli Studi Di Perugia
Curated by ChEMBL
TargetQuinolone resistance protein NorA(Staphylococcus aureus)
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of Staphylococcus aureus 1199B NorA assessed as reduction in ethidium bromide efflux by fluorescence assayMore data for this Ligand-Target Pair
TargetQuinolone resistance protein NorA(Staphylococcus aureus)
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux measured for 5 mins b...More data for this Ligand-Target Pair
TargetQuinolone resistance protein NorA(Staphylococcus aureus)
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of Staphylococcus aureus SA-1199B NorA assessed as reduction in EtBr efflux measured over 5 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetQuinolone resistance protein NorA(Staphylococcus aureus)
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Universita` Degli Studi Di Perugia
Curated by ChEMBL
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of NorA in Staphylococcus aureus SA-1199B expressing GrlA A116E mutant assessed as reduction in EtBr efflux incubated for 5 mins by fluore...More data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.02E+4nMAssay Description:TP_TRANSPORTER: increase in dihydrofluorescein intracellular accumulation (dihydrofluorescein: 1 uM) in SK-E2 cells (expressing BSEP)More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Federal University Of Parana
Curated by ChEMBL
Federal University Of Parana
Curated by ChEMBL
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human NCI-H460 cells mediated pheophorbide A efflux for 2 to 20 hr by fluorescence plate reader ana...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Federal University Of Parana
Curated by ChEMBL
Federal University Of Parana
Curated by ChEMBL
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of BCRP (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.38E+4nMT: 2°CAssay Description:Briefly, 3 uL of enzyme (approximately 20 nM LoxA, final concentration) or buffer (no-enzyme control) was dispensed into 1536-well Greiner black clea...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Federal University Of Parana
Curated by ChEMBL
Federal University Of Parana
Curated by ChEMBL
Affinity DataIC50: 2.63E+4nMAssay Description:Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.84E+4nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of human recombinant DNA topoisomerase1More data for this Ligand-Target Pair
