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Found 11 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase ATR' and Ligand = 'BDBM412060'
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi: <0.150nMAssay Description:Binding affinity to ATR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi: <0.200nMAssay Description:Binding affinity to ATR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi: <10nMAssay Description:Assays were carried out at 25° C. in the presence of 5 nM full-length ATR. An assay stock buffer solution was prepared containing all of the reagents...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi: <10nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi: <10nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi:  505nMAssay Description:Assays were carried out at 25° C. in the presence of 5 nM full-length ATR. An assay stock buffer solution was prepared containing all of the reagents...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi:  505nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi:  505nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi:  550nMAssay Description:Table 5: Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out i...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi:  3.00E+3nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ATR (unknown origin)-driven CHK1 phosphorylationMore data for this Ligand-Target Pair
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In DepthDetails PubMed