TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Binding affinity was evaluated using [3H]WIN-35428 binding to dopamine transporter (DAT) in rat caudate-putamenMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of Dopamine uptake in male Sprague-Dawley rats using [3H]DA ligandMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Binding affinity towards Sigma receptor type 2 in whole rat brain homogenates except cerebellum using radioligand ([3H]DTG) binding assay.More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute On Drug Abuse
Curated by ChEMBL
National Institute On Drug Abuse
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Inhibition of specific binding of [3H]3-PPP to sigma binding site in Guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute On Drug Abuse
Curated by ChEMBL
National Institute On Drug Abuse
Curated by ChEMBL
Affinity DataIC50: 589nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 690nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
Affinity DataIC50: 690nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute On Drug Abuse
Curated by ChEMBL
National Institute On Drug Abuse
Curated by ChEMBL
Affinity DataIC50: 780nMAssay Description:Inhibition of specific binding of [125I]PIPAG to sigma receptor in Guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Missouri-Columbia
Curated by ChEMBL
University Of Missouri-Columbia
Curated by ChEMBL
Affinity DataIC50: 960nMAssay Description:Displacement of [3H]pentazocine from sigma1 receptor in guinea pig membraneMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Missouri-Columbia
Curated by ChEMBL
University Of Missouri-Columbia
Curated by ChEMBL
Affinity DataIC50: 1.09E+3nMAssay Description:Displacement of [3H]pentazocine from sigma1 receptor in guinea pig membrane in presence of phenytoinMore data for this Ligand-Target Pair
TargetScavenger receptor class B member 1(Homo sapiens (Human))
Itherx Pharmaceuticals
Curated by ChEMBL
Itherx Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human SRB1-mediated Hepatitis C virus genotype 2a entry into human 293T cells by immunoblottingMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute On Drug Abuse
Curated by ChEMBL
National Institute On Drug Abuse
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of specific binding of [3H]DTG to sigma receptor in Guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute On Drug Abuse
Curated by ChEMBL
National Institute On Drug Abuse
Curated by ChEMBL
Affinity DataIC50: 1.48E+3nMAssay Description:Binding affinity was evaluated using [3H]pentazocine binding to sigma-1 receptor from guinea pig brainMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against the Dopamine receptor D2 in rat striatnrn by using [3H]spiperone radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro Dopamine receptor D2 affinity by using [3H]spiperone as the radioligand in rat limbic system at 1 uM concentration of compound.More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro binding affinity towards dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro 5-hydroxytryptamine 2 receptor affinity by using [3H]spiperone as the radioligand in rat cortical tissue.More data for this Ligand-Target Pair