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Found 2385 of ic50 for UniProtKB: Q86X55
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50258790((S)-2-amino-N-(3-(5-(5-(benzo[d]thiazol-7-yl)-1,3,...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50301077(2-(4-(2-(2,6-dimethoxyphenyl)-7-methyl-1H-benzo[d]...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50301079(2-(4-(2-(2-fluoro-6-methoxyphenyl)-7-methyl-1H-ben...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50301078(2-(4-(2-(4-fluoro-2-methoxyphenyl)-7-methyl-1H-ben...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50301076(2-(4-(2-(2-methoxyphenyl)-4-methyl-1H-benzo[d]imid...)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609320(CHEMBL5272699)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50301075(2-(4-(2-(2-methoxypyridin-3-yl)-3H-imidazo[4,5-b]p...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609337(CHEMBL5270700)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50301069(2-(4-(2-(2-methoxypyridin-3-yl)-4-methyl-1H-benzo[...)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609315(CHEMBL5274219)
Affinity DataIC50:  0.920nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609333(CHEMBL5291238)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609339(CHEMBL5271782)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50301073(2-(4-(2-(2-methoxypyridin-3-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609307(CHEMBL5288947)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609313(CHEMBL5283756)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609334(CHEMBL5287824)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50612685(CHEMBL5283866)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human PRMT4 by fluorescence-based SAHH-coupled assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609318(CHEMBL5271800)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50301074(2-(4-(2-(2-methoxypyridin-3-yl)-1-methyl-1H-benzo[...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50598022(CHEMBL5173678)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609306(CHEMBL5289496)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609300(CHEMBL5266562)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609319(CHEMBL5289683)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of FLAG-tagged CARM1 (unknown origin) (2 to 585 residues) using biotin-aminohexanoate-PRKQLATKAARMeKSAP-amide peptide as substrate preincu...More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609322(CHEMBL5284876)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT4 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT4 (unknown origin) using biotinylated histone H4 (1 to 24 residues) as substrate in presence of [3H]SAM by scintillation proximity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human PRMT4 assessed as inhibition of methylation activity using biotin-labeled peptide as substrate and [3H]-SAM by scintillation prox...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609332(CHEMBL5268692)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609317(CHEMBL5274541)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609324(CHEMBL5277620)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50301080(CHEMBL567298 | N-methyl-2-(4-(7-methyl-2-phenyl-1H...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human CARM1 assessed as inhibition of histone3 methylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609312(CHEMBL5273938)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609311(CHEMBL5279093)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50:  6nMAssay Description:Inhibition of FLAG-tagged CARM1 (unknown origin) (2 to 585 residues) using biotin-aminohexanoate-PRKQLATKAARMeKSAP-amide peptide as substrate preincu...More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609323(CHEMBL5290292)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609316(CHEMBL5269937)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50598020(CHEMBL5202088)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609301(CHEMBL4559961)
Affinity DataIC50: <10nMAssay Description:Inhibition of FLAG-tagged CARM1 (unknown origin) (2 to 585 residues) using biotin-aminohexanoate-PRKQLATKAARMeKSAP-amide peptide as substrate preincu...More data for this Ligand-Target Pair
Ligand InfoPDB
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609340(CHEMBL5289773)
Affinity DataIC50:  10nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609305(CHEMBL5290611)
Affinity DataIC50:  10nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609321(CHEMBL5266548)
Affinity DataIC50:  12nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609341(CHEMBL5270405)
Affinity DataIC50:  12nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609336(CHEMBL5285757)
Affinity DataIC50:  12nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50609335(CHEMBL5279447)
Affinity DataIC50:  13nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50194730(CHEMBL3906680)
Affinity DataIC50:  14nMAssay Description:Inhibition of human full length PRMT4 (1 to 608 residues) expressed in 293F cells assessed as inhibition of methylation activity preincubated with pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50194785(CHEMBL3956007)
Affinity DataIC50:  15nMAssay Description:Inhibition of human full length PRMT4 (1 to 608 residues) expressed in 293F cells assessed as inhibition of methylation activity preincubated with pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50194766(CHEMBL3938938)
Affinity DataIC50:  15nMAssay Description:Inhibition of human full length PRMT4 (1 to 608 residues) expressed in 293F cells assessed as inhibition of methylation activity preincubated with pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50194780(CHEMBL3911620)
Affinity DataIC50:  16nMAssay Description:Inhibition of human full length PRMT4 (1 to 608 residues) expressed in 293F cells assessed as inhibition of methylation activity preincubated with pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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