BDBM50598021 CHEMBL5191769

SMILES COC(=O)c1cc(O)c2cc(NC(=O)NCCCCNC(=N)NCCC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)ccc2c1

InChI Key InChIKey=DMXKZVDCWGJXLG-VBHAUSMQSA-N

Data  7 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50598021   

TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  1.33E+4nMAssay Description:Inhibition of human full length recombinant GST his-tagged PRMT3 (2 to 531 residues) using histone H4 as substrate incubated for 20 mins in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataKd:  52nMAssay Description:Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as dissociation constant by surface plasmon resonanceMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  4.34E+3nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT6 (2 to 375 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  4.68E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598021(CHEMBL5191769)
Affinity DataIC50:  778nMAssay Description:Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed