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Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50008068
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataKi:  330nMAssay Description:Inhibition of ROCK (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515427(CHEMBL4461288)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate incubated for 20 mins in presence of [gamma33P]ATP by filter binding me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515427(CHEMBL4461288)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate incubated for 20 mins in presence of [gamma33P]ATP by filter binding me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM14047(Aminofurazanyl-azabenzimidazole 6n | N-(3-{[2-(4-a...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of N-terminal His-tagged human ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AKRRRLSSLRA-CONH2 as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50365218(CHEMBL1956071 | GSK screening, 29)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of N-terminal His-tagged human ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AKRRRLSSLRA-CONH2 as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515428(CHEMBL4554795)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of recombinant human GST-tagged ROCK2 (1 to 552 residues) using myelin basic protein as substrate incubated for 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515428(CHEMBL4554795)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human GST-tagged ROCK1 (1 to 535 residues) using myelin basic protein as substrate incubated for 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515430(NETARSUDIL | US11608319, Compound AR-13324)
Affinity DataIC50:  11nMAssay Description:Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate incubated for 20 mins in presence of [gamma33P]ATP by filter binding me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515430(NETARSUDIL | US11608319, Compound AR-13324)
Affinity DataIC50:  33nMAssay Description:Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate incubated for 20 mins in presence of [gamma33P]ATP by filter binding me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515429(CHEMBL4471765)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human recombinant ROCK1 expressed in Baculovirus infected Sf9 cells assessed as inhibition of Ulight-RRRSLLE phosphorylation incubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515429(CHEMBL4471765)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of human recombinant ROCK2 expressed in Baculovirus infected Sf21 cells assessed as inhibition of Ulight-RRRSLLE phosphorylation incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515427(CHEMBL4461288)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to ROCK2 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515427(CHEMBL4461288)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to ROCK1 (unknown origin) incubated for 1 hrs by qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed