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Found 153 Enz. Inhib. hit(s) with Target = 'Protein mono-ADP-ribosyltransferase PARP3'
TargetProtein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataKd:  5.80nMAssay Description:Binding affinity to PARP3 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240716(US9422243, 14)
Affinity DataKd:  10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240720(US9422243, 20)
Affinity DataKd: <10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240717(US9422243, 15)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240714(US9422243, 12)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240713(US9422243, 11)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240718(US9422243, 18)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240719(US9422243, 19)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240704(US9422243, 1)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKd:  24nMAssay Description:Binding affinity to PARP3 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240711(US9422243, 8)
Affinity DataKd:  30nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240715(US9422243, 13)
Affinity DataKd:  34nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM167421(US9073893, 21)
Affinity DataKd:  40nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM167420(US9073893, 20)
Affinity DataKd:  50nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240721(US9422243, 21)
Affinity DataKd:  50nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240712(US9422243, 10)
Affinity DataKd:  70nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM27533(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pht...)
Affinity DataKd:  70nMAssay Description:Binding affinity to human PARP3 PARP domain by isothermal titration colorimetryMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240707(US9422243, 4)
Affinity DataKd:  90nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3(Mus musculus (Mouse))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM138355(US8877944, P1)
Affinity DataKd:  180nMAssay Description:The assay is based on the use of a probe of formula (IP) that binds to the NAD binding pocket and takes advantage of the significant change in the po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM209932(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-...)
Affinity DataKd:  231nMAssay Description:Binding affinity to PARP3 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataKd:  267nMAssay Description:Binding affinity to PARP3 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM167422(US9073893, 22)
Affinity DataKd:  270nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
Affinity DataKd:  700nMAssay Description:Binding affinity to human PARP3 PARP domain by isothermal titration colorimetryMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50277614(2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]py...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to human PARP3 PARP domain by isothermal titration colorimetryMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50226518(3-Aminobenzoesaeure | 3-aminobenzoic acid | CHEMBL...)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to human PARP3 PARP domain by isothermal titration colorimetryMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM124950(US8765972, 3)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of fluorescent probe from human recombinant His/GST-tagged PARP3 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM124951(US8765972, 4)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of fluorescent probe from human recombinant His/GST-tagged PARP3 by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM103554(STO1131 | US8551988, 39)
Affinity DataIC50:  6.00E+3nMAssay Description:Experiments todetermine IC50 values were conducted with compound concentrationsin the range between 10 nM and 450 μM with a DMSO concentrationof...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM103555(ME0354)
Affinity DataIC50: >1.00E+5nMAssay Description:Experiments todetermine IC50 values were conducted with compound concentrationsin the range between 10 nM and 450 μM with a DMSO concentrationof...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM103556(ME0355)
Affinity DataIC50:  1.30E+3nMAssay Description:Experiments todetermine IC50 values were conducted with compound concentrationsin the range between 10 nM and 450 μM with a DMSO concentrationof...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM103557(ME0327)
Affinity DataIC50:  1.53E+4nMAssay Description:Experiments todetermine IC50 values were conducted with compound concentrationsin the range between 10 nM and 450 μM with a DMSO concentrationof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM103558(ME0328)
Affinity DataIC50:  890nMAssay Description:Experiments todetermine IC50 values were conducted with compound concentrationsin the range between 10 nM and 450 μM with a DMSO concentrationof...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50: >1.00E+5nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM206061(US9255106, S3)
Affinity DataIC50:  66.9nMAssay Description:In order to test the selectivity of substituents on piperazinotriazole ring within the PARP family, the selectivity of compound S3 and positive compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  320nMAssay Description:In order to test the selectivity of substituents on piperazinotriazole ring within the PARP family, the selectivity of compound S3 and positive compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50104287(CHEMBL3594136)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of full-length human ARTD3 using 500 nM NAD substrate after 1 hrs incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50104288(CHEMBL3594137)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of full-length human ARTD3 using 500 nM NAD substrate after 1 hrs incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50104285(CHEMBL3593716)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of full-length human ARTD3 using 500 nM NAD substrate after 1 hrs incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50104286(CHEMBL3593715)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of full-length human ARTD3 using 500 nM NAD substrate after 1 hrs incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50136755(CHEMBL3752386)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ARTD3 by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50136772(CHEMBL3752492)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ARTD3 by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50306253(1-(2-(pyridin-3-yl)acetyl)-2,3,9,9a-tetrahydro-1H-...)
Affinity DataIC50:  50nMAssay Description:Inhibition of PARP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50306256(1-(3-(pyrazin-2-yl)propanoyl)-2,3,9,9a-tetrahydro-...)
Affinity DataIC50:  70nMAssay Description:Inhibition of PARP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human PARP3 by trichloroacetic acid precipitation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50444027(CHEMBL3092523)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50444028(CHEMBL3092522)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50444029(CHEMBL3092521)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50444030(CHEMBL3092520)
Affinity DataIC50:  1.11E+4nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50444031(CHEMBL3092518)
Affinity DataIC50:  1.32E+4nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50444032(CHEMBL3092517)
Affinity DataIC50:  1.44E+4nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
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