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Found 20 Enz. Inhib. hit(s) with all data for entry = 2081
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352195(US9802920, Compound I-19 | [5-Amino-1-(4-phenoxy- ...)
Affinity DataIC50:  0.5nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352196(3-{4-[5-Amino-4-(6- morpholin-4-ylmethyl-1H- indol...)
Affinity DataIC50:  1nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352190(US9802920, Compound I-14 | {5-Amino-1-[4-(2,3- dif...)
Affinity DataIC50:  3nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352194(US9802920, Compound I-18 | {5-Amino-1-[4-(2,3-difl...)
Affinity DataIC50:  5nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352191(2-{4-[5-Amino-4-(1H- indole-2-carbonyl)-pyrazol- 1...)
Affinity DataIC50:  7nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352177(US9802920, Compound I-1 | [5-Amino-1-(3-fluoro-4- ...)
Affinity DataIC50:  41nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352184(US9802920, Compound I-8 | [5-Amino-1-(3-hydroxy-4-...)
Affinity DataIC50:  59nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352192(3-{4-[5-Amino-4-(1H- indole-2-carbonyl)-pyrazol- 1...)
Affinity DataIC50:  82nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352185(US9802920, Compound I-9 | [5-Amino-1-(2-methoxy-4-...)
Affinity DataIC50:  146nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352186(US9802920, Compound I-10 | [5-Amino-1-(2-hydroxy-4...)
Affinity DataIC50:  162nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352181(5-Amino-1-(3-chloro-4- phenoxy-phenyl)-1H- pyrazol...)
Affinity DataIC50:  216nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352193(3-{4-[5-Amino-4-(1H- benzoimidazole-2-carbonyl)- p...)
Affinity DataIC50:  230nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352179(US9802920, Compound I-3 | {5-Amino-1-[4-(pyridin-2...)
Affinity DataIC50:  502nMAssay Description:The assay is a capture of radioactive 33P phosphorylated product through filtration. The interactions of Btk, biotinylated SH2 peptide substrate (Src...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352183(US9802920, Compound I-7 | [5-Amino-1-(3-methoxy-4-...)
Affinity DataIC50:  552nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352178(US9802920, Compound I-2 | [5-Amino-1-(6-phenoxy- p...)
Affinity DataIC50:  869nMAssay Description:The assay is a capture of radioactive 33P phosphorylated product through filtration. The interactions of Btk, biotinylated SH2 peptide substrate (Src...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352188(US9802920, Compound I-12 | [5-Amino-1-(4- cyclopen...)
Affinity DataIC50: >1.00E+3nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352189(US9802920, Compound I-13 | {5-Amino-1-[4-(2,2- dim...)
Affinity DataIC50: >1.00E+3nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352182(US9802920, Compound I-6 | {5-Amino-1-[4-(3,4- difl...)
Affinity DataIC50:  1.00E+3nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Flouresence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352180(US9802920, Compound I-4 | {5-Amino-1-[4-(pyridin-3...)
Affinity DataIC50:  2.20E+4nMAssay Description:The assay is a capture of radioactive 33P phosphorylated product through filtration. The interactions of Btk, biotinylated SH2 peptide substrate (Src...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM352187(US9802920, Compound I-11 | [5-Amino-1-(4-isopropox...)
Affinity DataIC50:  7.39E+4nMAssay Description:The assay is a capture of radioactive 33P phosphorylated product through filtration. The interactions of Btk, biotinylated SH2 peptide substrate (Src...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent