Found 19 Enz. Inhib. hit(s) for PDB: 4JT5 TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 8nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
3D Structure (crystal)TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 8nMAssay Description:Inhibition of mTOR assessed as inhibition of gamma32ATP incorporation to histone H1 by phosphorimagingMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 8nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: <50nMAssay Description:This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 100nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit/Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 410nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta [525-1106] /Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 410nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR/Tyrosine-protein kinase HCK(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 1.20E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform/Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src/Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 1.40E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR/Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 1.50E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform/Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.More data for this Ligand-Target Pair
TargetEphrin type-B receptor 4/Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 3.40E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 3.60E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
TargetReceptor protein-tyrosine kinase/Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 4.40E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src/Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataIC50: 5.10E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataKd: 3nMAssay Description:Binding constant for MTOR kinase domainMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of California San Francisco
University Of California San Francisco
Affinity DataKd: 3nMAssay Description:Inhibition of human mTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
