Reaction Details Report a problem with these data
Target
Macrophage colony-stimulating factor 1 receptor [538-678,753-922]
Ligand
BDBM17749
Substrate
cFMS -Tie-2 Chimera
Meas. Tech.
cFMs Autophosphorylation Fluorescence Polarization End Point Assay.
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
1300±100 nM
Citation
Schalk-Hihi, C; Ma, HC; Struble, GT; Bayoumy, S; Williams, R; Devine, E; Petrounia, IP; Mezzasalma, T; Zeng, L; Schubert, C; Grasberger, B; Springer, BA; Deckman, IC Protein engineering of the colony-stimulating factor-1 receptor kinase domain for structural studies. J Biol Chem 282:4085-93 (2007) [PubMed] Article
More Info.:
Target
Name:
Macrophage colony-stimulating factor 1 receptor [538-678,753-922]
Synonyms:
6His.FMS.538-922(TIE2) | CSF1R | CSF1R_HUMAN | FMS | Tyrosine Kinase CSF1-R Mutant (Tie2 KID Chimera) | cFMS -Tie-2 Chimera
Type:
Other Protein Type
Mol. Mass.:
37574.75
Organism:
Homo sapiens (Human)
Description:
Recombinant protein contains FMS cytoplasmic domain (FMS538-922.6His), in which FMS KID was replaced with Tie-2 KID.
Residue:
333
Sequence:
GVDYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTASTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERD
Inhibitor
Name:
BDBM17749
Synonyms:
JNJ31117164
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Substrate
Name:
Macrophage colony-stimulating factor 1 receptor [538-678,753-922]
Synonyms:
6His.FMS.538-922(TIE2) | CSF1R | CSF1R_HUMAN | FMS | Tyrosine Kinase CSF1-R Mutant (Tie2 KID Chimera) | cFMS -Tie-2 Chimera
Type:
Other Protein Type
Mol. Mass.:
37574.75
Organism:
Homo sapiens (Human)
Description:
Recombinant protein contains FMS cytoplasmic domain (FMS538-922.6His), in which FMS KID was replaced with Tie-2 KID.
Residue:
333
Sequence:
GVDYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTASTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERD