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Target
L-lactate dehydrogenase
Ligand
BDBM23241
Substrate
BDBM23233
Meas. Tech.
Lactate Dehydrogenase Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
>200000±n/a nM
Citation
 Cameron, A; Read, J; Tranter, R; Winter, VJ; Sessions, RB; Brady, RL; Vivas, L; Easton, A; Kendrick, H; Croft, SL; Barros, D; Lavandera, JL; Martin, JJ; Risco, F; García-Ochoa, S; Gamo, FJ; Sanz, L; Leon, L; Ruiz, JR; Gabarró, R; Mallo, A; Gómez de las Heras, F Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity. J Biol Chem 279:31429-39 (2004) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase
Synonyms:
L-lactate dehydrogenase | LDH_PLAFD | Lactate Dehydrogenase | pfLDH
Type:
Oxidoreductase
Mol. Mass.:
34111.90
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
316
Sequence:
MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALA
  
Inhibitor
Name:
BDBM23241
Synonyms:
1,2,5-oxadiazole, OXD9 | ethyl 4-[(4-methoxyphenyl)methoxy]-1,2,5-oxadiazole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C13H14N2O5
Mol. Mass.:
278.2607
SMILES:
CCOC(=O)c1nonc1OCc1ccc(OC)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23233
Synonyms:
2-hydroxypropanoic acid | Lactate | Lactic Acid
Type:
Small organic molecule
Emp. Form.:
C3H6O3
Mol. Mass.:
90.0779
SMILES:
CC(O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: