Reaction Details Report a problem with these data
Target
Coagulation factor XI
Ligand
BDBM32749
Substrate
n/a
Meas. Tech.
Factor XIa Dose Response Confirmation
IC50
>50000±0 nM
Citation
 PubChem, PC Factor XIa Dose Response Confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Coagulation factor XI
Synonyms:
Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent
Type:
Enzyme
Mol. Mass.:
70130.58
Organism:
Homo sapiens (Human)
Description:
P03951
Residue:
625
Sequence:
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
  
Inhibitor
Name:
BDBM32749
Synonyms:
MLS000536748 | N-[(4-nitrophenoxy)-oxo-phenyl--sulfanylidene]carbamic acid ethyl ester | N-[keto-(4-nitrophenoxy)-phenyl-persulfuranylidene]carbamic acid ethyl ester | SMR000155660 | cid_2305429 | ethyl N-[(4-nitrophenoxy)-oxidanylidene-phenyl--sulfanylidene]carbamate | ethyl N-[(4-nitrophenoxy)-oxo-phenyl--sulfanylidene]carbamate
Type:
Small organic molecule
Emp. Form.:
C15H14N2O6S
Mol. Mass.:
350.346
SMILES:
CCOC(=O)N=S(=O)(Oc1ccc(cc1)[N+]([O-])=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: