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Target
Ubiquitin carboxyl-terminal hydrolase BAP1
Ligand
BDBM40269
Substrate
n/a
Meas. Tech.
BAP1 Enzyme inhibitors Dose Response Confirmation
IC50
>50000±n/a nM
Citation
 PubChem, PC BAP1 Enzyme inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase BAP1
Synonyms:
BAP1 | BAP1_HUMAN | KIAA0272 | Ubiquitin carboxyl-terminal hydrolase BAP1 (BRCA1-associated protein 1) (Cerebral protein 6).
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80364.15
Organism:
Homo sapiens (Human)
Description:
gi_68565074
Residue:
729
Sequence:
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
  
Inhibitor
Name:
BDBM40269
Synonyms:
MLS000033606 | N-(3-Cyano-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-2-(1-cyclohexyl-1H-tetrazol-5-ylsulfanyl)-acetamide | N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-(1-cyclohexyltetrazol-5-yl)sulfanylacetamide | N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-[(1-cyclohexyl-1,2,3,4-tetrazol-5-yl)sulfanyl]ethanamide | N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-[(1-cyclohexyl-5-tetrazolyl)thio]acetamide | N-(3-cyano-4,5,6,7-tetrahydrobenzothiophen-2-yl)-2-[(1-cyclohexyltetrazol-5-yl)thio]acetamide | SMR000003774 | cid_645846
Type:
Small organic molecule
Emp. Form.:
C18H22N6OS2
Mol. Mass.:
402.537
SMILES:
O=C(CSc1nnnn1C1CCCCC1)Nc1sc2CCCCc2c1C#N
Structure:
Search PDB for entries with ligand similarity: