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Target
Ubiquitin carboxyl-terminal hydrolase BAP1
Ligand
BDBM40287
Substrate
n/a
Meas. Tech.
BAP1 Enzyme inhibitors Dose Response Confirmation
IC50
>50000±n/a nM
Citation
 PubChem, PC BAP1 Enzyme inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase BAP1
Synonyms:
BAP1 | BAP1_HUMAN | KIAA0272 | Ubiquitin carboxyl-terminal hydrolase BAP1 (BRCA1-associated protein 1) (Cerebral protein 6).
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80364.15
Organism:
Homo sapiens (Human)
Description:
gi_68565074
Residue:
729
Sequence:
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
  
Inhibitor
Name:
BDBM40287
Synonyms:
MLS000091972 | N-butyl-4-keto-6-(p-phenetylsulfamoyl)-1H-quinoline-3-carboxamide | N-butyl-6-[(4-ethoxyphenyl)sulfamoyl]-4-oxidanylidene-1H-quinoline-3-carboxamide | N-butyl-6-[(4-ethoxyphenyl)sulfamoyl]-4-oxo-1H-quinoline-3-carboxamide | N-butyl-6-{[(4-ethoxyphenyl)amino]sulfonyl}-4-oxo-1,4-dihydroquinoline-3-carboxamide | SMR000026496 | cid_3235803
Type:
Small organic molecule
Emp. Form.:
C22H25N3O5S
Mol. Mass.:
443.516
SMILES:
CCCCNC(=O)c1cnc2ccc(cc2c1O)S(=O)(=O)Nc1ccc(OCC)cc1
Structure:
Search PDB for entries with ligand similarity: