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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM75994
Substrate
n/a
Meas. Tech.
Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1)
IC50
>614.38±n/a nM
Citation
 PubChem, PC Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) PubChem Bioassay (2011)[AID] 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM75994
Synonyms:
1-(2-thienyl)-2-[[6-(2-thienyl)pyridazin-3-yl]thio]ethanone | 1-thiophen-2-yl-2-(6-thiophen-2-ylpyridazin-3-yl)sulfanyl-ethanone | 1-thiophen-2-yl-2-(6-thiophen-2-ylpyridazin-3-yl)sulfanylethanone | 1-thiophen-2-yl-2-[(6-thiophen-2-yl-3-pyridazinyl)thio]ethanone | MLS000678474 | SMR000323960 | cid_7207253
Type:
Small organic molecule
Emp. Form.:
C14H10N2OS3
Mol. Mass.:
318.437
SMILES:
O=C(CSc1ccc(nn1)-c1cccs1)c1cccs1
Structure:
Search PDB for entries with ligand similarity: