Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (fumarate)
Ligand
BDBM50240898
Substrate
n/a
Meas. Tech.
ChEMBL_1791599 (CHEMBL4263518)
IC50
251189±n/a nM
Citation
 Chibli, LA; Schmidt, TJ; Nonato, MC; Calil, FA; Da Costa, FB Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. Eur J Med Chem 157:852-866 (2018) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (fumarate)
Synonyms:
1.3.98.1 | DHODH | Dihydroorotate dehydrogenase (fumarate) | Dihydroorotate oxidase
Type:
PROTEIN
Mol. Mass.:
34659.43
Organism:
Leishmania major
Description:
ChEMBL_118088
Residue:
320
Sequence:
MSLQVNLLNNTFANPFMNAAGVMCTTTEELVAMTESASGSLVSKSCTPALREGNPTPRYQALPLGSINSMGLPNNGFDFYLAYAAEQHDYGKKPLFLSMSGLSMRENVEMCKRLAAVATEKGVILELNLSCPNVPGKPQVAYDFDAMRQCLTAVSEVYPHSFGVKMPPYFDFAHFDAAAEILNEFPKVQFITCINSIGNGLVIDAETESVVIKPKQGFGGLGGRYVLPTALANINAFYRRCPGKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALQEEGPSIFERLTSELLGVMAKKRYQTLDEFRGKVRTLDGTAESTR
  
Inhibitor
Name:
BDBM50240898
Synonyms:
5,7-Dihydroxy-3,6-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one | 5,7-dihydroxy-3,6,4'-trimethoxyflavone | CHEMBL161957 | SANTIN
Type:
Small organic molecule
Emp. Form.:
C18H16O7
Mol. Mass.:
344.3154
SMILES:
COc1ccc(cc1)-c1oc2cc(O)c(OC)c(O)c2c(=O)c1OC
Structure:
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