Reaction Details Report a problem with these data
Target
Chromobox protein homolog 7
Ligand
BDBM50538808
Substrate
n/a
Meas. Tech.
ChEMBL_1977189 (CHEMBL4610324)
Kd
700±n/a nM
Citation
 Milosevich, N; McFarlane, J; Gignac, MC; Li, J; Brown, TM; Wilson, CR; Devorkin, L; Croft, CS; Hof, R; Paci, I; Lum, JJ; Hof, F Pan-specific and partially selective dye-labeled peptidic inhibitors of the polycomb paralog proteins. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Chromobox protein homolog 7
Synonyms:
CBX7 | CBX7_HUMAN | Chromobox protein homolog 7 | Chromobox protein homolog 7 (CBX7)
Type:
Protein
Mol. Mass.:
28351.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
251
Sequence:
MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF
  
Inhibitor
Name:
BDBM50538808
Synonyms:
CHEMBL4646516
Type:
Small organic molecule
Emp. Form.:
C54H68N9O12S
Mol. Mass.:
1067.235
SMILES:
CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(N)=O |r,wU:13.13,4.3,70.75,wD:8.8,58.63,(35.09,-7.72,;35.09,-9.26,;36.42,-10.04,;33.75,-10.04,;33.75,-11.58,;32.42,-12.34,;31.09,-11.58,;31.09,-10.04,;29.75,-12.34,;29.75,-13.89,;28.42,-11.58,;27.08,-12.34,;27.08,-13.89,;25.74,-11.58,;25.74,-10.04,;27.08,-9.26,;28.42,-10.04,;29.75,-9.27,;29.75,-7.72,;28.41,-6.96,;27.08,-7.73,;24.41,-12.34,;23.07,-11.58,;23.07,-10.04,;21.74,-12.34,;20.41,-11.58,;19.07,-12.34,;17.75,-11.57,;17.75,-10.04,;16.42,-12.34,;15.09,-11.57,;13.77,-12.34,;12.44,-11.57,;12.44,-10.03,;13.78,-9.27,;15.1,-10.04,;13.78,-7.73,;15.11,-6.97,;13.37,-6.24,;11.12,-9.26,;9.8,-10.02,;9.79,-11.55,;8.47,-12.31,;7.13,-11.54,;5.8,-12.3,;7.14,-10.01,;8.47,-9.25,;8.47,-7.71,;9.81,-6.95,;9.81,-5.44,;11.12,-4.68,;11.13,-3.14,;12.45,-5.44,;12.44,-6.97,;11.12,-7.72,;35.09,-12.34,;35.09,-13.89,;36.42,-11.58,;37.76,-12.34,;37.76,-13.89,;39.09,-14.66,;39.09,-16.2,;40.43,-16.97,;40.43,-18.51,;41.76,-19.28,;39.09,-19.28,;40.42,-20.04,;39.09,-11.58,;39.09,-10.04,;40.43,-12.34,;41.76,-11.58,;41.76,-10.04,;43.09,-9.26,;43.09,-12.34,;44.43,-11.58,;43.09,-13.89,)|
Structure:
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