Reaction Details Report a problem with these data
Target
Chromobox protein homolog 7
Ligand
BDBM50538813
Substrate
n/a
Meas. Tech.
ChEMBL_1977189 (CHEMBL4610324)
Kd
1500±n/a nM
Citation
 Milosevich, N; McFarlane, J; Gignac, MC; Li, J; Brown, TM; Wilson, CR; Devorkin, L; Croft, CS; Hof, R; Paci, I; Lum, JJ; Hof, F Pan-specific and partially selective dye-labeled peptidic inhibitors of the polycomb paralog proteins. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Chromobox protein homolog 7
Synonyms:
CBX7 | CBX7_HUMAN | Chromobox protein homolog 7 | Chromobox protein homolog 7 (CBX7)
Type:
Protein
Mol. Mass.:
28351.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
251
Sequence:
MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF
  
Inhibitor
Name:
BDBM50538813
Synonyms:
CHEMBL4643012
Type:
Small organic molecule
Emp. Form.:
C75H95N12O17S
Mol. Mass.:
1468.691
SMILES:
CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C1CCCC1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O |r,wU:6.6,32.34,53.56,68.71,wD:2.1,41.44,59.62,17.18,(15.82,-23.23,;17.15,-22.46,;17.15,-20.91,;15.8,-20.15,;14.48,-20.92,;14.48,-22.47,;13.13,-20.16,;13.13,-18.61,;14.46,-17.83,;15.79,-18.61,;17.13,-17.83,;17.12,-16.28,;15.77,-15.51,;14.45,-16.29,;11.8,-20.93,;10.45,-20.17,;10.45,-18.62,;9.12,-20.94,;9.13,-22.48,;7.8,-23.26,;6.47,-22.49,;5.14,-23.26,;5.15,-24.8,;6.5,-25.56,;7.82,-24.78,;7.79,-20.18,;7.78,-18.64,;6.44,-17.88,;9.11,-17.86,;18.48,-20.14,;18.48,-18.59,;19.83,-20.9,;21.16,-20.13,;21.16,-18.58,;22.4,-17.67,;21.92,-16.2,;20.37,-16.2,;19.9,-17.67,;22.51,-20.89,;22.51,-22.44,;23.84,-20.12,;25.18,-20.88,;25.19,-22.43,;26.53,-23.2,;26.53,-24.74,;27.88,-25.51,;27.88,-27.05,;29.23,-27.83,;26.55,-27.84,;27.87,-28.6,;26.52,-20.11,;26.51,-18.56,;27.86,-20.87,;29.2,-20.1,;29.19,-18.55,;30.53,-17.77,;30.54,-20.86,;30.55,-22.41,;31.88,-20.08,;33.21,-20.85,;33.21,-22.39,;34.55,-23.16,;34.55,-24.7,;35.88,-25.46,;33.22,-25.47,;34.54,-20.08,;34.54,-18.54,;35.87,-20.85,;37.21,-20.08,;37.2,-18.54,;38.54,-17.77,;38.53,-16.23,;39.86,-15.46,;39.86,-13.92,;38.53,-13.15,;37.2,-13.93,;38.53,-11.62,;37.19,-10.85,;37.2,-9.31,;35.87,-8.54,;34.53,-9.31,;34.54,-10.86,;35.87,-11.62,;33.21,-11.64,;33.22,-13.17,;31.67,-11.62,;33.2,-8.55,;33.21,-7,;34.52,-6.23,;34.52,-4.7,;33.18,-3.94,;33.17,-2.41,;31.87,-4.72,;31.88,-6.24,;30.54,-7,;30.54,-8.54,;29.21,-9.3,;29.2,-10.85,;27.87,-11.61,;30.54,-11.62,;31.89,-10.86,;31.88,-9.32,;38.54,-20.85,;39.87,-20.08,;38.54,-22.38,)|
Structure:
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