Reaction Details Report a problem with these data
Target
Receptor-type tyrosine-protein phosphatase C
Ligand
BDBM50099721
Substrate
n/a
Meas. Tech.
ChEMBL_39938 (CHEMBL655779)
IC50
22000±n/a nM
Citation
 Urbanek, RA; Suchard, SJ; Steelman, GB; Knappenberger, KS; Sygowski, LA; Veale, CA; Chapdelaine, MJ Potent reversible inhibitors of the protein tyrosine phosphatase CD45. J Med Chem 44:1777-93 (2001) [PubMed]  Article 
Target
Name:
Receptor-type tyrosine-protein phosphatase C
Synonyms:
CD45 | CD_antigen=CD45 | L-CA | Leukocyte common antigen | PTPRC | PTPRC_HUMAN | Receptor-type tyrosine-protein phosphatase C (CD45) | T200
Type:
Protein
Mol. Mass.:
147474.19
Organism:
Homo sapiens (Human)
Description:
P08575
Residue:
1306
Sequence:
MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
  
Inhibitor
Name:
BDBM50099721
Synonyms:
6-Benzoyl-[1,2]naphthoquinone | CHEMBL51529
Type:
Small organic molecule
Emp. Form.:
C17H10O3
Mol. Mass.:
262.2595
SMILES:
O=C(c1ccccc1)c1ccc2C(=O)C(=O)C=Cc2c1 |c:17|
Structure:
Search PDB for entries with ligand similarity: