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Found 525 with Last Name = 'steelman' and Initial = 'gb'
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091753(CHEMBL405854 | H-Ser-Leu-Arg-Arg-Ser-Ser-cyclic(Cy...)
Affinity DataKi:  0.0590nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061031((S)-1-[(S)-2-(4-Benzenesulfonylaminocarbonyl-benzo...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091751(CHEMBL411542 | Cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Asp...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091751(CHEMBL411542 | Cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Asp...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036095(2-[5-Cyclohexanesulfonylamino-2-(4-fluoro-phenyl)-...)
Affinity DataKi:  0.210nMAssay Description:In vitro inhibition of human leukocyte elastase mediated hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091758((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091758((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061028((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061047(((S)-2,2-Difluoro-5-methyl-4-{[(S)-1-((S)-3-methyl...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061043(CHEMBL106592 | [(S)-1-((S)-2-{(S)-3,3-Difluoro-1-i...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061037(CHEMBL302961 | {(S)-1-[(S)-2-((S)-3-Carbamoyl-3,3-...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091752((S)-3-{(2S,3S)-2-[(S)-5-Guanidino-2-(2-{4-[(naphth...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091752((S)-3-{(2S,3S)-2-[(S)-5-Guanidino-2-(2-{4-[(naphth...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091761((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091757(CHEMBL264744 | Cyclic-(Cys-Phe-Gly-Gly-Ala-Ile-Asp...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091757(CHEMBL264744 | Cyclic-(Cys-Phe-Gly-Gly-Ala-Ile-Asp...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031210(2-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-m...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061035(2-((S)-3-Methyl-2-{[(S)-1-((S)-3-methyl-2-phenoxyc...)
Affinity DataKi:  0.640nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061044(2-((S)-3-Methyl-2-{[(S)-1-((S)-3-methyl-2-phenoxyc...)
Affinity DataKi:  0.640nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061049(2-[(S)-2-({(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3...)
Affinity DataKi:  0.650nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091753(CHEMBL405854 | H-Ser-Leu-Arg-Arg-Ser-Ser-cyclic(Cy...)
Affinity DataKi:  0.650nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061054(CHEMBL110125 | CHEMBL66128 | {(S)-1-[(S)-2-((S)-4-...)
Affinity DataKi:  0.810nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061036(CHEMBL304114 | {(S)-1-[(S)-2-((S)-3,3-Difluoro-1-i...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036124((2-(4-Fluoro-phenyl)-1-{[2-methyl-1-(4,4,5,5-tetra...)
Affinity DataKi:  0.960nMAssay Description:In vitro inhibition of human leukocyte elastase mediated hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061027(((S)-4-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-met...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058344(CHEMBL417935 | {(S)-2-Methyl-1-[(S)-2-((S)-3,3,3-t...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091754(Arg-Ser-Ser-cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Asp-Ar...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061023(CHEMBL323231 | CHEMBL68577 | {(S)-1-[(S)-2-((S)-4-...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036109(2-[5-Cyclohexanesulfonylamino-2-(4-fluoro-phenyl)-...)
Affinity DataKi:  1.60nMAssay Description:In vitro inhibition of human leukocyte elastase mediated hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061052(CHEMBL110364 | [(S)-1-((S)-2-{(S)-3,3-Difluoro-1-i...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061040(CHEMBL2370419 | {(S)-2-Methyl-1-[(S)-2-(3,3,3-trif...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061045(CHEMBL110174 | {(S)-1-[(S)-2-((S)-4-Acetylamino-3,...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036058(CHEMBL354883 | benzyl (S)-1-((S)-2-(((S)-1,1,1-tri...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50426352(CHEMBL2321996)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant DAT expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061038(CHEMBL308415 | {(S)-1-[(S)-2-((S)-3,3-Difluoro-1-i...)
Affinity DataKi:  3nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061039((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50426355(CHEMBL2321991)
Affinity DataKi:  3.30nMAssay Description:Inhibition of human recombinant NET expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058391((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058391((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061046(CHEMBL110400 | [(S)-2,2-Difluoro-4-({(S)-1-[(S)-2-...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50037338(CHEMBL325234 | {6-(3-Chloro-phenyl)-2-oxo-1-[(3,3,...)
Affinity DataKi:  3.5nMAssay Description:Tested for inhibitory activity against human leukocyte elastase(HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036100(CHEMBL11398 | {2-(4-Amino-phenyl)-6-oxo-1-[(3,3,3-...)
Affinity DataKi:  3.60nMAssay Description:In vitro inhibition of human leukocyte elastase mediated hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50037340(CHEMBL112880 | {6-(3,5-Dimethoxy-phenyl)-2-oxo-1-[...)
Affinity DataKi:  3.80nMAssay Description:Tested for inhibitory activity against human leukocyte elastase(HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061048((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50021218((S)-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoli...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant NET expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50005548((+)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinol...)
Affinity DataKi:  4nMAssay Description:Inhibition of NET in rat synaptosomal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50426353(CHEMBL2321993)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant NET expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061041(CHEMBL108504 | CHEMBL305259 | {(S)-1-[(S)-2-((S)-4...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50426357(CHEMBL2326695)
Affinity DataKi:  4.20nMAssay Description:Inhibition of human recombinant DAT expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50037333(CHEMBL113132 | {6-(3-tert-Butoxy-phenyl)-2-oxo-1-[...)
Affinity DataKi:  4.40nMAssay Description:Tested for inhibitory activity against human leukocyte elastase(HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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