Reaction Details
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Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50301375
Substrate
n/a
Meas. Tech.
ChEMBL_1995677 (CHEMBL4629572)
EC50
12000±n/a nM
Citation
Gellrich, L; Heitel, P; Heering, J; Kilu, W; Pollinger, J; Goebel, T; Kahnt, A; Arifi, S; Pogoda, W; Paulke, A; Steinhilber, D; Proschak, E; Wurglics, M; Schubert-Zsilavecz, M; Chaikuad, A; Knapp, S; Bischoff, I; Fürst, R; Merk, D l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPAR?. J Med Chem 63:6727-6740 (2020) [PubMed] Article More Info.:
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARγ) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Inhibitor
Name:
BDBM50301375
Synonyms:
3,3',5,5'-tetraiodo-L-thyronine | 3,5,3',5'-tetraiodo-L-thyronine | 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine | CHEMBL1624 | L-T4 | L-thyroxine | O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine | levothyroxine
Type:
Small organic molecule
Emp. Form.:
C15H11I4NO4
Mol. Mass.:
776.87
SMILES:
N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O |r|
Structure:
