Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM12751
Substrate
n/a
Meas. Tech.
ChEMBL_49329 (CHEMBL875001)
Ki
0.013000±n/a nM
Citation
Song, Y; Clizbe, L; Bhakta, C; Teng, W; Li, W; Wu, Y; Jia, ZJ; Zhang, P; Wang, L; Doughan, B; Su, T; Kanter, J; Woolfrey, J; Wong, P; Huang, B; Tran, K; Sinha, U; Park, G; Reed, A; Malinowski, J; Hollenbach, S; Scarborough, RM; Zhu, BY Design, synthesis, and SAR of substituted acrylamides as factor Xa inhibitors. Bioorg Med Chem Lett 12:1511-5 (2002) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Inhibitor
Name:
BDBM12751
Synonyms:
1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide | CHEMBL152854 | CHEMBL37251 | SN-429
Type:
Small organic molecule
Emp. Form.:
C24H22N6O3S
Mol. Mass.:
474.535
SMILES:
Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(c1)C(N)=N