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Found 2791 with Last Name = 'huang' and Initial = 'b'
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12751(1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamo...)
Affinity DataKi:  0.0130nMAssay Description:Tested for binding affinity against human Coagulation factor Xa (trypsin-like serine protease)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12751(1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamo...)
Affinity DataKi:  0.0130nMAssay Description:Inhibitory activity of the compound against Coagulation factor Xa (serine protease) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM207217(US9260439, 194 | US9260439, 238 | US9260439, 239)
Affinity DataKi: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM340314((Scheme A): Preparation of 2,2-difluoroethyl (3S)-...)
Affinity DataKi: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
LigandPNGBDBM340384(US9758538, Example 72)
Affinity DataKi: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM340336(US9758538, Example 24)
Affinity DataKi: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM207196(US9260439, 173)
Affinity DataKi: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM207378(US9260439, 262)
Affinity DataKi: <0.0180nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM340346(US9758538, Example 34)
Affinity DataKi:  0.0190nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM340391(US9758538, Example 79)
Affinity DataKi:  0.0210nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM207028(US9260439, 10 | US9260439, 4)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM207236(US9260439, 213)
Affinity DataKi: <0.0230nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM207172(US9260439, 149)
Affinity DataKi: <0.0290nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM207391(US9260439, 275)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM370133(US10233188, Example 22 | US10800783, Example 22 | ...)
Affinity DataKi:  0.0470nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM467013((-)-6-(2,2-difluoroethyl)-8-[(1R*,2R*)-2-hydroxy-2...)
Affinity DataKi:  0.0640nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM207234(US9260439, 211)
Affinity DataKi:  0.0780nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM207239(US9260439, 216)
Affinity DataKi:  0.0840nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM370147(US10233188, Example 36 | US10800783, Example 36 | ...)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM340352(US9758538, Example 40)
Affinity DataKi:  0.0950nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50609170(CHEMBL5266837)
Affinity DataKi:  0.100nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50246967(CHEMBL4080228 | US10570121, Example 81)
Affinity DataKi: <0.100nMAssay Description:Binding affinity to EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM467013((-)-6-(2,2-difluoroethyl)-8-[(1R*,2R*)-2-hydroxy-2...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM370205(US10233188, Example 92 | US10800783, Example 92 | ...)
Affinity DataKi:  0.120nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM207061(US9260439, 38)
Affinity DataKi:  0.120nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM340347(US9758538, Example 35)
Affinity DataKi:  0.140nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM207043(US9260439, 20)
Affinity DataKi:  0.150nMAssay Description:Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50586108(CHEMBL5094608)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]-naloxone from mouse mu opioid receptor expressed in CHO cell membranes assessed as inhibition constant incubated for 1.5 hrs by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50586084(CHEMBL5094575)
Affinity DataKi:  0.170nMAssay Description:Binding affinity to mouse mu opioid receptor expressed in CHO cells in presence of naltrexone incubated for 1.5 hrs by competitive radioligand bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113598((Z)-3-(3-Carbamimidoyl-4-fluoro-phenyl)-2-fluoro-b...)
Affinity DataKi:  0.180nMAssay Description:Inhibitory activity of the compound against factor Xa,activity expressed as Ki nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM370256(BDBM467151 | US10233188, Example 143)
Affinity DataKi:  0.190nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM467013((-)-6-(2,2-difluoroethyl)-8-[(1R*,2R*)-2-hydroxy-2...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM370257(BDBM467152 | US10233188, Example 144)
Affinity DataKi:  0.196nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM370113(8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(m...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50609166(CHEMBL5280928)
Affinity DataKi:  0.200nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM370120(6-chloro-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50586092(CHEMBL5081372)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to mouse mu opioid receptor expressed in CHO cells in presence of naltrexone incubated for 1.5 hrs by competitive radioligand bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50586103(CHEMBL5087231)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to mouse mu opioid receptor expressed in CHO cells in presence of naltrexone incubated for 1.5 hrs by competitive radioligand bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50586137(CHEMBL5085590)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-naloxone from mouse mu opioid receptor expressed in CHO cell membranes assessed as inhibition constant incubated for 1.5 hrs by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50609166(CHEMBL5280928)
Affinity DataKi:  0.200nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50586093(CHEMBL5082472)
Affinity DataKi:  0.210nMAssay Description:Binding affinity to mouse mu opioid receptor expressed in CHO cells in presence of naltrexone incubated for 1.5 hrs by competitive radioligand bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50586128(CHEMBL5089829)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]-naloxone from mouse mu opioid receptor expressed in CHO cell membranes assessed as inhibition constant incubated for 1.5 hrs by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50586139(CHEMBL5092405)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]-naloxone from mouse mu opioid receptor expressed in CHO cell membranes assessed as inhibition constant incubated for 1.5 hrs by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50609171(CHEMBL5288078)
Affinity DataKi:  0.210nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50586139(CHEMBL5092405)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]-diprenorphine from mouse kappa opioid receptor expressed in CHO cell membranes assessed as inhibition constant incubated for 1.5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50586126(CHEMBL5081715)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]-naloxone from mouse mu opioid receptor expressed in CHO cell membranes assessed as inhibition constant incubated for 1.5 hrs by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50586120(CHEMBL5085221)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]-naloxone from mouse mu opioid receptor expressed in CHO cell membranes assessed as inhibition constant incubated for 1.5 hrs by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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