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Target
Histone deacetylase 2b
Ligand
BDBM50135756
Substrate
n/a
Meas. Tech.
ChEMBL_87717 (CHEMBL857174)
IC50
1000±n/a nM
Citation
 Mai, A; Massa, S; Cerbara, I; Valente, S; Ragno, R; Bottoni, P; Scatena, R; Loidl, P; Brosch, G 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity. J Med Chem 47:1098-109 (2004) [PubMed]  Article 
Target
Name:
Histone deacetylase 2b
Synonyms:
Histone deacetylase HD2
Type:
PROTEIN
Mol. Mass.:
30785.07
Organism:
Zea mays
Description:
ChEMBL_87549
Residue:
286
Sequence:
MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVEKHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQNNEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEMSEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSEQSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
  
Inhibitor
Name:
BDBM50135756
Synonyms:
CHEMBL411020 | N-Hydroxy-3-[(E)-1-methyl-4-(3-phenyl-acryloyl)-1H-pyrrol-2-yl]-acrylamide | N-Hydroxy-3-{1-methyl-4-[(E)-(3-phenyl-acryloyl)]-1H-pyrrol-2-yl}-acrylamide
Type:
Small organic molecule
Emp. Form.:
C17H16N2O3
Mol. Mass.:
296.3205
SMILES:
Cn1cc(cc1\C=C\C(=O)NO)C(=O)\C=C\c1ccccc1
Structure:
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