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Target
Histone deacetylase 2b
Ligand
BDBM50139942
Substrate
n/a
Meas. Tech.
ChEMBL_87549 (CHEMBL695147)
IC50
110±n/a nM
Citation
 Mai, A; Massa, S; Cerbara, I; Valente, S; Ragno, R; Bottoni, P; Scatena, R; Loidl, P; Brosch, G 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity. J Med Chem 47:1098-109 (2004) [PubMed]  Article 
Target
Name:
Histone deacetylase 2b
Synonyms:
Histone deacetylase HD2
Type:
PROTEIN
Mol. Mass.:
30785.07
Organism:
Zea mays
Description:
ChEMBL_87549
Residue:
286
Sequence:
MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVEKHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQNNEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEMSEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSEQSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
  
Inhibitor
Name:
BDBM50139942
Synonyms:
(5S,8S,11S)-5,8-Dimethyl-11-(6-oxiranyl-6-oxo-hexyl)-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone | CHEMBL12942
Type:
Small organic molecule
Emp. Form.:
C22H36N4O6
Mol. Mass.:
452.5444
SMILES:
C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCCCCC(=O)C2CO2)NC(=O)CCCCCNC1=O
Structure:
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