Reaction Details Report a problem with these data
Target
Histone deacetylase 2b
Ligand
BDBM50173886
Substrate
n/a
Meas. Tech.
ChEMBL_322291 (CHEMBL885046)
IC50
37±n/a nM
Citation
 Mai, A; Massa, S; Rotili, D; Pezzi, R; Bottoni, P; Scatena, R; Meraner, J; Brosch, G Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates. Bioorg Med Chem Lett 15:4656-61 (2005) [PubMed]  Article 
Target
Name:
Histone deacetylase 2b
Synonyms:
Histone deacetylase HD2
Type:
PROTEIN
Mol. Mass.:
30785.07
Organism:
Zea mays
Description:
ChEMBL_87549
Residue:
286
Sequence:
MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVEKHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQNNEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEMSEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSEQSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
  
Inhibitor
Name:
BDBM50173886
Synonyms:
7-(4-Benzyl-6-oxo-1,6-dihydro-pyrimidin-2-ylsulfanyl)-heptanoic acid hydroxyamide | CHEMBL198624
Type:
Small organic molecule
Emp. Form.:
C18H23N3O3S
Mol. Mass.:
361.459
SMILES:
ONC(=O)CCCCCCSc1nc(Cc2ccccc2)cc(=O)[nH]1
Structure:
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