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Target
Acyl-protein thioesterase 1
Ligand
BDBM50368267
Substrate
n/a
Meas. Tech.
ChEMBL_100184 (CHEMBL706217)
IC50
110000±n/a nM
Citation
 Van Schepdael, A; Busson, R; Vanderhaeghe, HJ; Claes, PJ; Verbist, L; Mingeot-Leclercq, MP; Brasseur, R; Tulkens, PM New derivatives of kanamycin B obtained by combined modifications in positions 1 and 6". Synthesis, microbiological properties, and in vitro and computer-aided toxicological evaluation. J Med Chem 34:1483-92 (1991) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 1
Synonyms:
Acyl-protein thioesterase 1/2 | Apt1 | LYPA1_RAT | Lypla1 | Lysosomal phospholipase A1
Type:
PROTEIN
Mol. Mass.:
24708.49
Organism:
Rattus norvegicus
Description:
ChEMBL_12731
Residue:
230
Sequence:
MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSSHIKYICPHAPVMPVTLNMSMMMPSWFDIIGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLMFGSLTVERLKGLVNPANVTFKVYEGMMHSSCQQEMMDVKYFIDKLLPPID
  
Inhibitor
Name:
BDBM50368267
Synonyms:
KANAMYCIN B | Kanamycin | Kantrex | Klebcil
Type:
Small organic molecule
Emp. Form.:
C18H37N5O10
Mol. Mass.:
483.5139
SMILES:
NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O |r|
Structure:
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