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Target
Voltage-dependent calcium channel subunit alpha-2/delta-1
Ligand
BDBM50080153
Substrate
n/a
Meas. Tech.
ChEMBL_348646 (CHEMBL866255)
IC50
8900±n/a nM
Citation
Burgos-Lepley, CE; Thompson, LR; Kneen, CO; Osborne, SA; Bryans, JS; Capiris, T; Suman-Chauhan, N; Dooley, DJ; Donovan, CM; Field, MJ; Vartanian, MG; Kinsora, JJ; Lotarski, SM; El-Kattan, A; Walters, K; Cherukury, M; Taylor, CP; Wustrow, DJ; Schwarz, JB Carboxylate bioisosteres of gabapentin. Bioorg Med Chem Lett 16:2333-6 (2006) [PubMed] Article
More Info.:
Target
Name:
Voltage-dependent calcium channel subunit alpha-2/delta-1
Synonyms:
CA2D1_RAT | Cacna2d1 | Cacnl2a | Cchl2a | Voltage-gated calcium channel alpha2/delta subunit 1
Type:
PROTEIN
Mol. Mass.:
123802.11
Organism:
Rattus norvegicus
Description:
ChEMBL_348646
Residue:
1091
Sequence:
MAAGCLLALTLTLFQSWLIGPSSEEPFPSPVTIKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLAMEAEKVQAAHQWREDFASNEVVYYNAKDDLDPERNESESGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTLLWQVFAADRLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFTFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYRYLALVLPTYSFYYIKAKIEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPREYCNDLKPSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRILLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPRMMRHLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSITDILQIGWWATAAAWSILQQLLLSLTFPRLLEAVEMEEDDFTASLSKQSCITEQTQYFFKNDTKSFSGLLDCGNCSRIFHVEKLMNTNLVFIMVESKGTCPCDTRLLMQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWSIFGLQFILLWLVSGSRHYLW
Inhibitor
Name:
BDBM50080153
Synonyms:
(1-Aminomethyl-cyclohexyl)-acetic acid | 2-(1-(aminomethyl)cyclohexyl)acetic acid | CHEMBL940 | CI-945 | GABAPENTIN | GOE-3450 | Neurontin | [1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID
Type:
Small organic molecule
Emp. Form.:
C9H17NO2
Mol. Mass.:
171.2368
SMILES:
NCC1(CC(O)=O)CCCCC1