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Target
Ubiquitin carboxyl-terminal hydrolase 2
Ligand
BDBM50436152
Substrate
n/a
Meas. Tech.
ChEMBL_968435 (CHEMBL2400586)
IC50
>31600±n/a nM
Citation
 Yamaguchi, M; Miyazaki, M; Kodrasov, MP; Rotinsulu, H; Losung, F; Mangindaan, RE; de Voogd, NJ; Yokosawa, H; Nicholson, B; Tsukamoto, S Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor. Bioorg Med Chem Lett 23:3884-6 (2013) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 2
Synonyms:
41 kDa ubiquitin-specific protease | Deubiquitinating enzyme 2 | UBP2_HUMAN | UBP41 | USP2 | Ubiquitin thioesterase 2 | Ubiquitin-specific-processing protease 2
Type:
PROTEIN
Mol. Mass.:
68093.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103660
Residue:
605
Sequence:
MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFLTRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNNCLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELCTLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
  
Inhibitor
Name:
BDBM50436152
Synonyms:
SPONGIACIDIN C
Type:
Small organic molecule
Emp. Form.:
C11H10N4O3
Mol. Mass.:
246.2221
SMILES:
O=C1NC(=O)\C(N1)=C1/CCNC(=O)c2[nH]ccc12
Structure:
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