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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50377964
Substrate
n/a
Meas. Tech.
ChEMBL_1362503 (CHEMBL3293104)
Ki
0.680000±n/a nM
Citation
 Yamashita, Y; Tanaka, K; Asano, T; Yamakawa, N; Kobayashi, D; Ishihara, T; Hanaya, K; Shoji, M; Sugai, T; Wada, M; Mashimo, T; Fukunishi, Y; Mizushima, T Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities. Bioorg Med Chem 22:3488-97 (2014) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50377964
Synonyms:
Cantil | Glycophenylate | MEPENZOLATE BROMIDE | Mepenzolate
Type:
Small organic molecule
Emp. Form.:
C21H26NO3
Mol. Mass.:
340.4355
SMILES:
C[N+]1(C)CCCC(C1)OC(=O)C(O)(c1ccccc1)c1ccccc1
Structure:
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