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Target
Delta-type opioid receptor
Ligand
BDBM88489
Substrate
n/a
Meas. Tech.
Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R)
EC50
>92487±n/a nM
Citation
 PubChem, PC Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors PubChem Bioassay (2012)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM88489
Synonyms:
(2Z)-2-(3,5-dimethoxybenzylidene)-5-[2-(4-hydroxyphenyl)ethynyl]coumaran-3-one | (2Z)-2-[(3,5-dimethoxyphenyl)methylidene]-5-[2-(4-hydroxyphenyl)ethynyl]-1-benzofuran-3-one | (2Z)-2-[(3,5-dimethoxyphenyl)methylidene]-5-[2-(4-hydroxyphenyl)ethynyl]-3-benzofuranone | MLS002473510 | SMR001397678 | cid_44202176
Type:
Small organic molecule
Emp. Form.:
C25H18O5
Mol. Mass.:
398.4074
SMILES:
COc1cc(OC)cc(\C=C2/Oc3ccc(cc3C2=O)C#Cc2ccc(O)cc2)c1
Structure:
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