Reaction Details Report a problem with these data
Target
Cytochrome P450 144
Ligand
BDBM50333117
Substrate
n/a
Meas. Tech.
Binding Assay
Kd
1.74e+5± 1.4e+4 nM
Citation
Driscoll, MD; McLean, KJ; Levy, C; Mast, N; Pikuleva, IA; Lafite, P; Rigby, SE; Leys, D; Munro, AW Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. J Biol Chem 285:38270-82 (2010) [PubMed] Article
More Info.:
Target
Name:
Cytochrome P450 144
Synonyms:
CP144_MYCTO | Cytochrome P450 144 (CYP144) | cyp144
Type:
Enzyme
Mol. Mass.:
47207.78
Organism:
Mycobacterium tuberculosis
Description:
P9WPL0
Residue:
434
Sequence:
MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ
Inhibitor
Name:
BDBM50333117
Synonyms:
(2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol | (2R,3S)-2-(2,4-Difluoro-phenyl)-3-(5-fluoro-pyrimidin-4-yl)-1-[1,2,4]triazol-1-yl-butan-2-ol | (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol | CHEMBL638 | UK-109496 | US11247981, Example Voriconazole | US9221791, Voriconazole | VORICONAZOLE | Vfend
Type:
Small organic molecule
Emp. Form.:
C16H14F3N5O
Mol. Mass.:
349.3105
SMILES:
C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F |r|