Reaction Details Report a problem with these data
Target
RNA-editing ligase 1, mitochondrial
Ligand
BDBM52639
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1).
IC50
34043±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay (2014)[AID] 
Target
Name:
RNA-editing ligase 1, mitochondrial
Synonyms:
REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52299.36
Organism:
Trypanosoma brucei brucei
Description:
gi_342179211
Residue:
469
Sequence:
MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIEIDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENFFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLPNGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNLLYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKHNVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAANDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTLAFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE
  
Inhibitor
Name:
BDBM52639
Synonyms:
(1,3-dimethylbenzimidazol-3-ium-2-yl)-(4-morpholinophenyl)diazene;besylate | MLS000689048 | SMR000283163 | benzenesulfonate;(1,3-dimethyl-2-benzimidazol-3-iumyl)-[4-(4-morpholinyl)phenyl]diazene | benzenesulfonate;(1,3-dimethylbenzimidazol-3-ium-2-yl)-(4-morpholin-4-ylphenyl)diazene | cid_15272053
Type:
Small organic molecule
Emp. Form.:
C19H22N5O
Mol. Mass.:
336.4103
SMILES:
Cn1c(\N=N\c2ccc(cc2)N2CCOCC2)[n+](C)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: