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Target
RNA-editing ligase 1, mitochondrial
Ligand
BDBM128127
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1).
IC50
>96559±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay (2014)[AID] 
Target
Name:
RNA-editing ligase 1, mitochondrial
Synonyms:
REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52299.36
Organism:
Trypanosoma brucei brucei
Description:
gi_342179211
Residue:
469
Sequence:
MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIEIDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENFFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLPNGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNLLYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKHNVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAANDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTLAFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE
  
Inhibitor
Name:
BDBM128127
Synonyms:
2-(4-chlorobenzyl)-1-cyclohexyl-3-phenyl-guanidine | 2-[(4-chlorophenyl)methyl]-1-cyclohexyl-3-phenyl-guanidine | 2-[(4-chlorophenyl)methyl]-1-cyclohexyl-3-phenylguanidine | MLS000694976 | N-(4-chlorobenzyl)-N'-cyclohexyl-N''-phenylguanidine | SMR000334853 | cid_3773682
Type:
Small organic molecule
Emp. Form.:
C20H24ClN3
Mol. Mass.:
341.878
SMILES:
Clc1ccc(C\N=C(\NC2CCCCC2)Nc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: