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Target
RNA-editing ligase 1, mitochondrial
Ligand
BDBM128132
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1).
IC50
>96559±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay (2014)[AID] 
Target
Name:
RNA-editing ligase 1, mitochondrial
Synonyms:
REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52299.36
Organism:
Trypanosoma brucei brucei
Description:
gi_342179211
Residue:
469
Sequence:
MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIEIDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENFFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLPNGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNLLYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKHNVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAANDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTLAFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE
  
Inhibitor
Name:
BDBM128132
Synonyms:
3-(2-bromanyl-4,6-dimethyl-phenoxy)-N-(phenylmethyl)propan-1-amine;ethanedioic acid | 3-(2-bromo-4,6-dimethylphenoxy)-N-(phenylmethyl)-1-propanamine;oxalic acid | MLS001008087 | N-benzyl-3-(2-bromo-4,6-dimethylphenoxy)-1-propanamine oxalate | N-benzyl-3-(2-bromo-4,6-dimethylphenoxy)propan-1-amine;oxalic acid | SMR000497571 | benzyl-[3-(2-bromo-4,6-dimethyl-phenoxy)propyl]amine;oxalic acid | cid_2934463
Type:
Small organic molecule
Emp. Form.:
C20H24BrNO5
Mol. Mass.:
438.312
SMILES:
OC(=O)C(O)=O.Cc1cc(C)c(OCCCNCc2ccccc2)c(Br)c1
Structure:
Search PDB for entries with ligand similarity: