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Target
RNA-editing ligase 1, mitochondrial
Ligand
BDBM128198
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1).
IC50
19721±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay (2014)[AID] 
Target
Name:
RNA-editing ligase 1, mitochondrial
Synonyms:
REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52299.36
Organism:
Trypanosoma brucei brucei
Description:
gi_342179211
Residue:
469
Sequence:
MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIEIDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENFFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLPNGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNLLYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKHNVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAANDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTLAFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE
  
Inhibitor
Name:
BDBM128198
Synonyms:
1-[(2-keto-3H-1,3-benzoxazol-6-yl)sulfonyl]-N-sec-butyl-isonipecotamide | MLS004496567 | N-(butan-2-yl)-1-[(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)sulfonyl]piperidine-4-carboxamide | N-butan-2-yl-1-[(2-oxidanylidene-3H-1,3-benzoxazol-6-yl)sulfonyl]piperidine-4-carboxamide | N-butan-2-yl-1-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]-4-piperidinecarboxamide | N-butan-2-yl-1-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonyl]piperidine-4-carboxamide | SMR003290627 | cid_60159341
Type:
Small organic molecule
Emp. Form.:
C17H23N3O5S
Mol. Mass.:
381.447
SMILES:
CCC(C)NC(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]c(=O)oc2c1
Structure:
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