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Target
DNA-directed RNA polymerase subunit alpha
Ligand
BDBM466516
Substrate
n/a
Meas. Tech.
Assay of Inhibition of Escherichia coli RNA Polymerase
IC50
1900±n/a nM
Citation
 Ebright, RH; Shen, J Arylpropionyl-triketone antibacterial agents US Patent  US10800725 Publication Date 10/13/2020 
Target
Name:
DNA-directed RNA polymerase subunit alpha
Synonyms:
JW3257 | RNA polymerase subunit alpha | RNAP subunit alpha | RPOA_ECOLI | Transcriptase subunit alpha | pez | phs | rpoA | sez
Type:
PROTEIN
Mol. Mass.:
36497.18
Organism:
Escherichia coli K-12
Description:
ChEMBL_106172
Residue:
329
Sequence:
MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLRDVRQPEVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIADE
  
Inhibitor
Name:
BDBM466516
Synonyms:
US10800725, Compound 4
Type:
Small organic molecule
Emp. Form.:
C31H46O5
Mol. Mass.:
498.6939
SMILES:
COc1ccccc1CCC(=O)C1=C(O)C(CCC(C)C)=C(O)C(CCC(C)C)(CCC(C)C)C1=O |c:13,t:21|
Structure:
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