Reaction Details
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DNA-directed RNA polymerase subunit alpha
Ligand
BDBM466517
Substrate
n/a
Meas. Tech.
Assay of Inhibition of Mycobacterium tuberculosis RNA Polymerase
IC50
1100±n/a nM
Citation
Ebright, RH; Shen, J Arylpropionyl-triketone antibacterial agents US Patent US10800725 Publication Date 10/13/2020 More Info.:
Target
Name:
DNA-directed RNA polymerase subunit alpha
Synonyms:
RNA polymerase subunit alpha | RNAP subunit alpha | RPOA_MYCTU | Transcriptase subunit alpha | rpoA
Type:
Protein
Mol. Mass.:
37685.84
Organism:
n/a
Description:
P9WGZ1
Residue:
347
Sequence:
MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNLKSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHNPGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIGRIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKNSISPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIKLHQLGLSLKDSPPSFDPSEVAGYDVATGTWSTEGAYDEQDYAETEQL
Inhibitor
Name:
BDBM466517
Synonyms:
US10800725, Compound 5
Type:
Small organic molecule
Emp. Form.:
C31H46O5
Mol. Mass.:
498.6939
SMILES:
COc1cccc(CCC(=O)C2=C(O)C(CCC(C)C)=C(O)C(CCC(C)C)(CCC(C)C)C2=O)c1 |c:11,t:19|
Structure:
