Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM468584
Substrate
n/a
Meas. Tech.
TBD
IC50
<1000±n/a nM
Citation
Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Greenlee, W Compounds for treatment of immune inflammatory disorders US Patent US10807952 Publication Date 10/20/2020
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM468584
Synonyms:
1-(2-((2S,4R)-4- fluoro-2-(2-fluoro- 3-(2-methyl-1H- benzo[d]imidazol- 5- yl)phenylcarbamoyl) pyrrolidin-1-yl)-2- oxoethyl)-1H- indazole-3- carboxamide | US10807952, Cmp No. 10
Type:
Small organic molecule
Emp. Form.:
C29H25F2N7O3
Mol. Mass.:
557.5507
SMILES:
Cc1nc2cc(ccc2[nH]1)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F |r|