Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM468628
Substrate
n/a
Meas. Tech.
TBD
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Greenlee, W Compounds for treatment of immune inflammatory disorders US Patent  US10807952 Publication Date 10/20/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM468628
Synonyms:
1-(2-((2S,4R)-2-(3- (3-cyano-1H- indazol-6-yl)-2- fluorophenyl- carbamoyl)-4- fluoropyrrolidin-1- yl)-2-oxoethyl)-1H- indazole-3- carboxamide | US10807952, Cmp No. 32
Type:
Small organic molecule
Emp. Form.:
C29H22F2N8O3
Mol. Mass.:
568.5336
SMILES:
NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(-c3ccc4c(n[nH]c4c3)C#N)c2F)c2ccccc12 |r|
Structure:
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