Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM468689
Substrate
n/a
Meas. Tech.
TBD
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Greenlee, W Compounds for treatment of immune inflammatory disorders US Patent  US10807952 Publication Date 10/20/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM468689
Synonyms:
(2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-N-(3- (6-chloro-9H-purin- 2-yl)-2- fluorophenyl)-4- fluoropyrrolidine-2- carboxamide | US10807952, Cmp No. 99
Type:
Small organic molecule
Emp. Form.:
C27H21ClF2N8O3
Mol. Mass.:
578.957
SMILES:
CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2nc(Cl)c3nc[nH]c3n2)c2ccccc12 |r|
Structure:
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