Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 7
Ligand
BDBM475952
Substrate
n/a
Meas. Tech.
Kinase Activity Assay
IC50
>1000±n/a nM
Citation
 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Inhibitors of cyclin-dependent kinase 7 (CDK7) US Patent  US10865206 Publication Date 12/15/2020 
Target
Name:
Cyclin-dependent kinase 7
Synonyms:
39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit
Type:
Enzyme Subunit
Mol. Mass.:
39047.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
346
Sequence:
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
  
Inhibitor
Name:
BDBM475952
Synonyms:
US10865206, Compound 114
Type:
Small organic molecule
Emp. Form.:
C30H33ClN6O3
Mol. Mass.:
561.074
SMILES:
CC(C)(C)OC(=O)Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: