Compile Data Set for Download or QSAR
Report error Found 197 of affinity data for UniProtKB/TrEMBL: O15303
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataEC50:  55nMAssay Description:Activation of human metabotropic glutamate 6 receptor expressed in golden hamster AV12-664 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50434134(CHEMBL2381641)
Affinity DataIC50: 267nMAssay Description:Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)
Affinity DataEC50:  280nMAssay Description:Compound was tested for the inhibition of Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50089890(4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxyli...)
Affinity DataKi:  400nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50074749(LY379268 | (1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1...)
Affinity DataEC50:  401nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50434137(CHEMBL2381649)
Affinity DataEC50:  709nMAssay Description:Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50299471(Ethyl 2-amino-4-methyl-5-phenylthiophene-3-carboxy...)
Affinity DataIC50: 750nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255435(CHEMBL4101970)
Affinity DataEC50:  760nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50434131(CHEMBL2381644)
Affinity DataEC50:  780nMAssay Description:Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)
Affinity DataKi:  900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataKi:  900nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50601004(CHEMBL5202739)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at mGlu6 receptor (unknown origin) expressed in human Flp-In-T-REx-293 cells by luciferase based GloSensor cAMP AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255407(CHEMBL4077705)
Affinity DataEC50:  1.07E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255347(CHEMBL4081842)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50434139(CHEMBL2381650)
Affinity DataEC50:  1.27E+3nMAssay Description:Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50434136(CHEMBL2381640)
Affinity DataIC50: 1.38E+3nMAssay Description:Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50434135(CHEMBL2381652)
Affinity DataEC50:  1.41E+3nMAssay Description:Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50446782(CHEMBL3114672)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50434130(CHEMBL2381645)
Affinity DataIC50: 1.89E+3nMAssay Description:Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50:  1.95E+3nMAssay Description:Agonist activity at human mGlu6 receptor expressed in hamster AV12 cells co-expressing rat EAAT1 assessed as inhibition of forskolin-stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50217031((1S,2R)-1-amino-2-phosphonomethylcyclopropane-carb...)
Affinity DataEC50:  1.95E+3nMAssay Description:Agonist activity at mGlu6 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50299477(Propyl 2-amino-4-methyl-5-phenylthiophene-3-carbox...)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255348(CHEMBL4085558)
Affinity DataEC50:  2.40E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataEC50:  2.40E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255389(CHEMBL4072781)
Affinity DataEC50:  2.40E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50089897(4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxyl...)
Affinity DataKi:  2.40E+3nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50074750(LY-389795 | 4-Amino-2-thia-bicyclo[3.1.0]hexane-4,...)
Affinity DataEC50:  2.43E+3nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM17664(CHEMBL284377 | L-serine O-phosphate | (2S)-2-amino...)
Affinity DataKi:  2.70E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255415(CHEMBL4078629)
Affinity DataEC50:  2.90E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataEC50:  2.99E+3nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataKi:  3.00E+3nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50434133(CHEMBL2381643)
Affinity DataIC50: 3.04E+3nMAssay Description:Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255437(CHEMBL4085750)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50446782(CHEMBL3114672)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255336(CHEMBL4064187)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50434138(CHEMBL2381651)
Affinity DataEC50:  3.25E+3nMAssay Description:Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataIC50: 3.30E+3nMAssay Description:Antagonist activity at recombinant human mGlu6 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as inhibition of L-AP4-inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataEC50:  3.36E+3nMAssay Description:Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50217030((1S,2S)-1-amino-2-phosphonomethylcyclopropane-carb...)
Affinity DataEC50:  3.41E+3nMAssay Description:Agonist activity at mGlu6 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50121643(CHEMBL3616847)
Affinity DataEC50:  3.45E+3nMAssay Description:Agonist activity at human recombinant mGlu6 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50299481(2-isothiocyanato-4-methyl-5-phenylthiophene-3-carb...)
Affinity DataIC50: 3.50E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50299478(Tert-Butyl 2-amino-4-methyl-5-phenylthiophene-3-ca...)
Affinity DataIC50: 3.60E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255340(CHEMBL4072316)
Affinity DataEC50:  3.60E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255292(CHEMBL4061423)
Affinity DataEC50:  3.60E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255346(CHEMBL4085327)
Affinity DataEC50:  3.90E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255390(CHEMBL4091029)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50255403(CHEMBL4101241)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50031704(2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-ami...)
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
Displayed 1 to 50 (of 197 total ) | Next | Last >>
Jump to: